Enhancing motor sequence learning in Parkinson’s disease through transcranial direct current stimulation of the primary motor cortex and the cerebellum.
In this project, we will investigate implicit motor sequence learning (IMSL) in persons with Parkinson’s disease (PD). IMSL is the inherent ability to learn numerous skills consisting of multiple single movements that are performed in a specific sequential order (e.g. reaching, dressing, typing and playing the piano). This crucial form of cognitive function, which is also known to be directly related to motor function, has been shown to be affected in PD. In recent years, transcranial direct current stimulation (tDCS) has gained considerable interest in the treatment of PD patients. This non-invasive brain stimulation technique has already demonstrated significant improvements in IMSL in healthy subjects when delivered over the primary motor cortex, as well as the cerebellum. The primary research objective of the current project is to determine potential effects of tDCS delivered over (a) the primary motor cortex and (b) the cerebellum to promote IMSL in patients with PD. Secondarily, we will identify which type of tDCS should be applied to which type of PD patient, based on their predominant clinical characteristics. Consequently, we will develop systematic tDCS protocols as a basis for future research and clinical applications in PD patients.
More information: https://researchportal.vub.be/en/publications/does-transcranial-direct-current-stimulation-of-the-primary-motor
Funding: FWO PhD Fellowship fundamental research Mahyar Firouzi
RERE PIs: Prof. Eva Swinnen